Peptide synthesis is a process that makes short sequences of polypeptides as it adds one amino acid at a time. This process is necessary to create particular sequences representing epitopes of specific protein domains that may or may not be modified by moieties, including phosphate groups. These short sequences are necessary for injection into animals for antibody production against that polypeptide.
What are the advantages of solid-phase peptide synthesis?
Removing unwanted soluble compounds becomes easy
The order of reactions can be controlled
Polypeptides prepared with the solid phase method are ones in which the first amino acids in the sequence are attached to a polymer substrate. Anything attached to the polymer becomes insoluble. Thus it becomes easy to make them separate from soluble molecules that are washed away. A chain of peptides anchored to a polymer also shows the desired chemical reactions between free-floating amino acids and the existing chain easier. The chain is held in place to reduce the randomness within the aqueous system.
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For peptide synthesis, free amino acids are modified by chemical groups. This protects them from reacting with other molecules in the system. Different chemical groups are used. Distinct chemical treatments can treat each of them. Thus the scientist can control what amino acids will react first, which ones second, and so on and so forth. Thus this makes sure that only the desired amino acid that is next in the sequence builds a connection to the anchored chain.
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